EPITALON® Spray - Dietary Supplement for Cyrcadian Rhythms Normalisation

• Type: Dietary supplement 
• Action: Normazilation of the functional state of the biorhythms 
• Form: Oral spray (20ml)
• Ingredient: Peptide AEDG (EPITALON®) 
• Manufactured: in Portugal
• Registration: Certified in EU

Scientific articles about the function of the peptide bioregulator:

• Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, Mironova E, Pulcini R, Robuffo I, Bologna G, Simeone P, Lanuti P, Guarnieri S, Trofimova S, Procopio AD, Toniato E. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci. 2022 Mar 25;23(7):3607. doi: 10.3390/ijms23073607. PMID: 35408963; PMCID: PMC8999041.
• Linkova NS, Khavinson VKh, Chalisova NI, Katanugina AS, Koncevaya EA. Peptidegic stimulation of differentiation of pineal immune cells. Bull Exp Biol Med. 2011 Nov;152(1):124-7. English, Russian. doi: 10.1007/s10517-011-1470-1. PMID: 22803057.
• Sinjari B, Diomede F, Khavinson V, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S. Short Peptides Protect Oral Stem Cells from Ageing. Stem Cell Rev Rep. 2020 Feb;16(1):159-166. doi: 10.1007/s12015-019-09921-3. PMID: 31677028.
• Korkushko OV, Lapin BA, Goncharova ND, Khavinson VKh, Shatilo VB, Vengerin AA, Antoniuk-Shcheglova IA, Magdich LV. [Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people]. Adv Gerontol. 2007;20(1):74-85. Russian. PMID: 17969590.
• Kozina LS, Arutjunyan AV, Khavinson VKh. Antioxidant properties of geroprotective peptides of the pineal gland. Arch Gerontol Geriatr. 2007;44 Suppl 1:213-6. doi: 10.1016/j.archger.2007.01.029. PMID: 17317455.
• Lezhava T, Monaselidze J, Kadotani T, Dvalishvili N, Buadze T. Anti-aging peptide bioregulators induce reactivation of chromatin. Georgian Med News. 2006 Apr;(133):111-5. PMID: 16705247.